As glaciers shrink, a major study reveals remarkable biodiversity across the world’s glacier-fed streams, providing a global reference for future climate-change microbiology studies on this vanishing ecosystem.

EZH1 steadies gene-reading machinery and adjusts DNA packaging, ensuring genes activate on time to maintain 24-hour rhythms.

A much-hyped new theory that purports to provide a universal explanation of natural phenomena merely repackages existing theoretical tools.

Mangrove soils are affected by the accumulation of plastic waste, but they may also hold a key to reduce its environmental impacts.

The complex history of the bread wheat D genome demonstrates the potential of wild relatives in crop improvement.

Drier climate and livestock grazing pressure jointly help to shape the diversity of plant traits in drylands worldwide.

Viral RNA elements induce controlled inflammation to trigger bone repair, which could be used to treat osteoporosis and other diseases.

Beneficial bacteria localize and flourish within coral tissues, boosting resilience to heat and other stressors.

An efficient long-read sequencing technique that searches for complex genomic variants provides accurate molecular diagnosis for genetic disorders within hours.

Improved understanding of the salt- tolerance mechanism in salt-loving plants could help progress seawater-based agriculture.

Manipulating DNA repair pathway boosts the accuracy of CRISPR technology.

An open-access catalog of the global ocean genome offers novel taxonomical and functional insights and unlocks the potential of blue biotechnology

Platform for identifying genetic variation in plant species could aid in crop improvement and sustainable agriculture.

Protocol boosts regenerative capabilities of stem cells previously wasted in transplant medicine.

Powered by logic and large language models, DeepGO-SE predicts the biological role of proteins and could be used to aid drug discovery.

An integrated shuffler optimizes the privacy of personal genomic data used for machine learning.

Analyses of sediment cores highlight declining nutrient availability and increased trace metal pollution in the Red Sea.

Researchers propose a pathway to create sustainable greening initiatives in the Middle East using existing technologies.

Inspired by large language models that power ChatGPT, an AI algorithm offers a new way to annotate cells.

An open-source, automated and cost-effective platform for COVID-19 diagnosis and analysis of genetic variants can be built from readily available materials, with big possibilities on the horizon.

Better understanding of the roles of plant hormones could help to engineer advantageous traits into rice and other crops.

An emerging conservation strategy could help wildlife to become more resilient against a range of environmental threats.

An open-source software can help align artificial intelligence applications in healthcare with data privacy regulations.

Uncovering PfAP2-P’s role in parasite's immune evasion and development, opening doors to innovative anti-malaria approaches.

Skin organoids offer a powerful platform for drug discovery in the ongoing fight against the virus formerly known as monkeypox.

Comparison of different nuclear magnetic resonance spectroscopy methods has helped to identify the most robust approach for studying different types of biomolecules.

An innovative AI-based tool leverages varied symptom descriptions, along with evidence from the scientific literature and genomic datasets, to pinpoint disease-associated gene variants.

New research into how humans and animals use complexity to make decisions offers some tantalizing insights into the nature of intelligence.

Hydrogels that mimic natural environments help to reveal cellular intricacies often missed in traditional lab studies.

Marine ecosystem models should account for vast fluctuation in dissolved oxygen.

Mutations on a key SARS-CoV-2 viral protein are linked to extreme immune responses and could offer a novel vaccine target.

A complex interplay of factors influences the spread of superbug genes during wastewater treatment and reuse.

PNP editing emerges as a versatile and programmable tool for site-specific DNA manipulations.

Drugs that inhibit a key protein should offer new targeted cancer therapy for leukemia and breast cancer.

A first complete genome map of einkorn reveals evolutionary origins and potential for enhanced wheat breeding.

Tiny packets of molecular cargo shed by cancer cells seed the foundations for metastasis at distant sites in the body.

Fundamental research offers opportunities for new varieties of pigmented rice and a resource to address malnutrition.

More effort is needed to bring salt-tolerant crops to the farmers who need them.

Biopharming technique yields cost-effective and environmentally friendly antimicrobial peptides.

Pioneering single-cell sequencing technology sheds light on risk of mitochondrial genome editing and hidden mitochondrial mutations in human oocytes and synthetic embryos.

A newly found protein complex plays a vital role in RNA protection and stability during its journey between DNA and the cell’s protein factory.

Evolution of lactate-mediated nerve signaling probably enabled memory systems, a comparative gene study shows.

Structural biology study reveals dynamics of DNA ligation during genome replication.

Textbook model of lagging-strand synthesis may be too simplistic for human DNA.

Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy.

Studying the molecular motion of proteins reveals previously unseen binding sites that could be targeted by new drug candidate molecules.

An enzyme from a Red Sea bacterium suppresses the formation of a slimy biofilm that helps propagate hospital-acquired infections.

Revealing zinc’s interaction with a critical transport protein underscores the need to study biological pathways under physiologically relevant conditions.

Elaborate interaction discovered between epigenetic regulatory protein and its activating lipid partner.

Blocking the overexpression of specific repeat RNA sequences could prove promising for the treatment of premature aging syndromes.

Heat-loving bacteria from an Antarctic volcano could help degrade and clean up oil in the world’s coldest continent and beyond.

The generation of a high-quality genome from a coral specimen reveals an alternative pathway for cysteine biosynthesis in animals and cautions against overreliance on model organisms.

Enhancement of adhesion molecules improves the ability of blood-forming stem cells to take root in transplant recipients.

Deep molecular analysis of the bone marrow microenvironment reveals that the cells regulating blood stem cell maintenance are more diverse than expected and have features likely to be conserved between species.

Fiddler crabs and other burrowing creatures could support the future of nutrient-deficient soils of dried-up mangroves.

Abnormal protein tied to Wiskott-Aldrich syndrome found to control gene splicing.

Nanotechnology that accelerates the transition of stem cells into bone could advance regenerative medicine. 

Stem cell analyses could reveal how extra doses of some genes lead to the characteristics seen in males born with one or more surplus X chromosomes.

Insight into the function of the nucleocapsid protein could help develop drugs that reduce coronavirus impact.

Cell processes and research reproducibility may be significantly impacted by changes in batch cultures as cells grow. More monitoring and improved procedures are needed.

The three-dimensional structure of a protein complex that is key for replicating damaged DNA offers insights into its regulation.

Molecules move within elongated protrusions to help stabilize migrating cells inside the bloodstream.

An in vitro cellular model that mimics the initial phase of human embryo creation could improve understanding of infertility.

The biomedical research community needs to do more to ensure their findings are relevant and reproducible.

An approach that reduces the computational power required to analyze huge amounts of DNA data for identifying new microbes and their proteins could be used for manufacturing anything from new antibiotics to plastic-degrading enzymes.

Honing a growth chamber cultivation technique leads to the identification of novel bacteria from Red Sea mangrove sediments.

Honeybees bring back more than just nectar from their floral feasts and these microbes may help them survive turbulent times.

Detailed and extensive genome sequencing of a subspecies of rat-infecting malaria parasites should instruct human malaria research.

A lot happens and changes within a thin one-meter-thick transition layer between deep Red Sea water and an expansive underlying brine lake.

Combining expertise has shed new light on how cells self-destruct during microbial infection. 

New method can simultaneously diagnose cases, track variants and detect co-infections.

Researchers show how bacteria have adapted a sensing mechanism that allows them to live in different environments. 

A mutational change of an enzyme’s dynamics increases its activity on a chromatin histone, ultimately causing a common lung cancer.

A low-cost diagnostic tool can detect a range of viruses without the need for expensive materials or facilities.

An interactive platform helps users visualize where SARS-CoV-2 mutations start, how wide they spread and how infectious they are.

Tiny light-emitting probes give researchers a better option for noninvasive imaging of living tissue.

A database of newly generated stem cell lines could provide the key to understanding the genetic factors that drive Klinefelter syndrome and related diseases.

Stem cell trafficking to the bone marrow is improved by an enzyme manufactured in silkworms and yeast.

A decades-old technique for probing protein motions proves more accurate than current practices.

Custom-fabricated lenses make it easy to attach high-tech microscopes directly to cell incubators.

A nutritious millet crop grown mainly in West Africa could be genetically improved for large-scale agriculture in Saudi Arabia.

A method that lights up tags attached to selected proteins can help to purify the proteins from a mixed protein pool.

A sequencing approach can home in on a rare mutation within a large number of cells, revealing implications for CRISPR genome editing and early cancer detection.

A likeness between genes of the SARS and COVID-19 viruses could inform research into potential treatments.

An assay for imaging the physical interactions between multiple cell populations could help cancer research and treatment assessment.

Discovery of a malaria parasite’s internal clock could lead to new treatment strategies 

Structural details of an enzyme complex shed light on DNA replication.

Copper ions could play a key role when peptide folding goes wrong and leads to harmful aggregates.

The conversion of skin cells into brain cells relies on proper insertion of L1 elements.

E-selectin is grown in silkworms for the first time, revealing new aspects of its binding dynamics.

Laser-based microscopes can tune into multiple biomolecular signatures found in cancer cells.

A machine learning method has identified highly elusive amino acid sequences involved in cell morphogenesis and adhesion and in diseases like cancer. 

What do an electrical engineer, an organic chemist, a materials scientist and a cell biologist all have in common? They invent and improve applications at the interface of biology and electronics. 

A protein, with a name reminiscent of legendary Greek sailors, has an unexpected role inside the human nucleus.

Protein-folded DNA nanostructures offer a new building material for biotechnology.

New experimental insights allow researchers to probe protein-DNA interactions with greater precision.

Protein found in gut-dwelling pathogens changes shape under human body temperatures, leading to toxins responsible for diarrheal disease.

Mutations in a repetitive protein motif are responsible for a rare cognitive disorder.

Understanding how bacterial metacommunities homogenize could help scientists predict future changes to ecosystems.

Single-molecule fluorescent measurements provide fresh insights into a process for keeping errors out of our genomes.