Fastening enzyme seals the deal in genome repair
Jan 24, 2023
Structural biology study reveals dynamics of DNA ligation during genome replication.
Article Collections
- Applied Mathematics and Computation Science
- Bioscience
- Chemical and Biological Engineering
- Chemical Science
- Computer Science
- Earth Science and Engineering
- Electrical Engineering
- Energy Resources and Petroleum Engineering
- Environmental Science and Engineering
- Marine Science
- Material Science and Engineering
- Mechanical Engineering
- Plant Science
- Statistics
Results for Bioscience
-
-
DNA replication in humans proves slow off the mark
Dec 14, 2022
Textbook model of lagging-strand synthesis may be too simplistic for human DNA.
-
Explaining the DNA repair mechanism
Dec 8, 2022
Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy.
-
Cryptic drug-binding sites discovered in the dance
Nov 21, 2022
Studying the molecular motion of proteins reveals previously unseen binding sites that could be targeted by new drug candidate molecules.
-
Bacterial quorum quenched by bacterial enzyme
Oct 18, 2022
An enzyme from a Red Sea bacterium suppresses the formation of a slimy biofilm that helps propagate hospital-acquired infections.
-
Zinc enhances albumin’s protective role against Parkinson's disease
Oct 16, 2022
Revealing zinc’s interaction with a critical transport protein underscores the need to study biological pathways under physiologically relevant conditions.
-
Complex regulation controls mediator of cancer growth
Oct 9, 2022
Elaborate interaction discovered between epigenetic regulatory protein and its activating lipid partner.
-
Finding an RNA target and tool to fight premature aging
Oct 4, 2022
Blocking the overexpression of specific repeat RNA sequences could prove promising for the treatment of premature aging syndromes.
-
Going to extremes to tackle oil contamination
Oct 2, 2022
Heat-loving bacteria from an Antarctic volcano could help degrade and clean up oil in the world’s coldest continent and beyond.
-
Coral genome reveals cysteine surprise
Sep 23, 2022
The generation of a high-quality genome from a coral specimen reveals an alternative pathway for cysteine biosynthesis in animals and cautions against overreliance on model organisms.
-
"Sticky" stem cells make for better transplants
Aug 24, 2022
Enhancement of adhesion molecules improves the ability of blood-forming stem cells to take root in transplant recipients.
-
Cell mapping close to the bone
Aug 16, 2022
Deep molecular analysis of the bone marrow microenvironment reveals that the cells regulating blood stem cell maintenance are more diverse than expected and have features likely to be conserved between species.
-
Burrowing crabs bring beneficial bacteria to mangroves
Aug 11, 2022
Fiddler crabs and other burrowing creatures could support the future of nutrient-deficient soils of dried-up mangroves.
-
Stem cells reveal underpinnings of rare immune disease
Jul 3, 2022
Abnormal protein tied to Wiskott-Aldrich syndrome found to control gene splicing.
-
Bone formation comes down to the nanowire
Jun 28, 2022
Nanotechnology that accelerates the transition of stem cells into bone could advance regenerative medicine.
-
Studying the genes behind surplus X chromosomes
Mar 29, 2022
Stem cell analyses could reveal how extra doses of some genes lead to the characteristics seen in males born with one or more surplus X chromosomes.
-
Disease severity linked to N protein of SARS-CoV-2
Mar 27, 2022
Insight into the function of the nucleocapsid protein could help develop drugs that reduce coronavirus impact.
-
Cell cultures not as stable as you'd think
Feb 8, 2022
Cell processes and research reproducibility may be significantly impacted by changes in batch cultures as cells grow. More monitoring and improved procedures are needed.
-
DNA replication under the microscope
Nov 21, 2021
The three-dimensional structure of a protein complex that is key for replicating damaged DNA offers insights into its regulation.
-
The complex dynamics of stem cell tethers and slings
Oct 6, 2021
Molecules move within elongated protrusions to help stabilize migrating cells inside the bloodstream.
-
Stem cell model for early human embryo development
Sep 8, 2021
An in vitro cellular model that mimics the initial phase of human embryo creation could improve understanding of infertility.
-
Getting cell culture research right
Aug 13, 2021
The biomedical research community needs to do more to ensure their findings are relevant and reproducible.
-
Equalizing the microbial research playing field
Jul 29, 2021
An approach that reduces the computational power required to analyze huge amounts of DNA data for identifying new microbes and their proteins could be used for manufacturing anything from new antibiotics to plastic-degrading enzymes.
-
Creating a lab mangrove helps to identify new bacteria
Jul 7, 2021
Honing a growth chamber cultivation technique leads to the identification of novel bacteria from Red Sea mangrove sediments.
-
Into the belly of the bee
Jun 13, 2021
Honeybees bring back more than just nectar from their floral feasts and these microbes may help them survive turbulent times.
-
Genetic treasure trove for malaria researchers
May 30, 2021
Detailed and extensive genome sequencing of a subspecies of rat-infecting malaria parasites should instruct human malaria research.
-
Deep and extreme: Microbes thrive in transition
May 23, 2021
A lot happens and changes within a thin one-meter-thick transition layer between deep Red Sea water and an expansive underlying brine lake.
-
Elegant constrictions in a cellular kill switch
May 4, 2021
Combining expertise has shed new light on how cells self-destruct during microbial infection.
-
All-in-one test for COVID-19 surveillance
Apr 20, 2021
New method can simultaneously diagnose cases, track variants and detect co-infections.
-
Atomic techniques reveal the evolution of a bacterial protein
Mar 21, 2021
Researchers show how bacteria have adapted a sensing mechanism that allows them to live in different environments.
-
Enzymatic danse macabre of lung cancer
Mar 15, 2021
A mutational change of an enzyme’s dynamics increases its activity on a chromatin histone, ultimately causing a common lung cancer.
-
Virus detection method is versatile and accessible
Feb 25, 2021
A low-cost diagnostic tool can detect a range of viruses without the need for expensive materials or facilities.
-
CovMT: Tracking virus mutations across the world
Feb 21, 2021
An interactive platform helps users visualize where SARS-CoV-2 mutations start, how wide they spread and how infectious they are.
-
Ultrabright dots see beyond skin deep
Feb 16, 2021
Tiny light-emitting probes give researchers a better option for noninvasive imaging of living tissue.
-
Biobank of stem cells helps understand genetic abnormalities
Jan 26, 2021
A database of newly generated stem cell lines could provide the key to understanding the genetic factors that drive Klinefelter syndrome and related diseases.
-
Enzyme biofactories to enhance cord blood transplants
Oct 21, 2020
Stem cell trafficking to the bone marrow is improved by an enzyme manufactured in silkworms and yeast.
-
Old methods prove true for studying proteins
Oct 12, 2020
A decades-old technique for probing protein motions proves more accurate than current practices.
-
Microscope lens inspired by lighthouse lenses
Oct 4, 2020
Custom-fabricated lenses make it easy to attach high-tech microscopes directly to cell incubators.
-
Genetic gains for better grains
Sep 29, 2020
A nutritious millet crop grown mainly in West Africa could be genetically improved for large-scale agriculture in Saudi Arabia.
-
Finding a handle to bag the right proteins
Sep 9, 2020
A method that lights up tags attached to selected proteins can help to purify the proteins from a mixed protein pool.
-
Barcoding long DNA quantifies CRISPR effects
Aug 26, 2020
A sequencing approach can home in on a rare mutation within a large number of cells, revealing implications for CRISPR genome editing and early cancer detection.
-
Studying COVID-19’s envelope protein
Jul 27, 2020
A likeness between genes of the SARS and COVID-19 viruses could inform research into potential treatments.
-
Multisample technique to analyze cell adhesion
Jul 5, 2020
An assay for imaging the physical interactions between multiple cell populations could help cancer research and treatment assessment.
-
Clocking in with malaria parasites
Jun 9, 2020
Discovery of a malaria parasite’s internal clock could lead to new treatment strategies
-
Stitching together the structure of the DNA replication toolbelt
May 17, 2020
Structural details of an enzyme complex shed light on DNA replication.
-
Untangling untidy folds to understand diseases
Apr 12, 2020
Copper ions could play a key role when peptide folding goes wrong and leads to harmful aggregates.
-
Jumping genes help make neurons in a dish
Mar 26, 2020
The conversion of skin cells into brain cells relies on proper insertion of L1 elements.
-
Silkworms provide new spin on sticky molecules
Mar 16, 2020
E-selectin is grown in silkworms for the first time, revealing new aspects of its binding dynamics.
-
Spotting cancer's greasy fingerprints
Jan 26, 2020
Laser-based microscopes can tune into multiple biomolecular signatures found in cancer cells.
-
LD Motif Finder locates ancient hidden protein patterns
Jan 6, 2020
A machine learning method has identified highly elusive amino acid sequences involved in cell morphogenesis and adhesion and in diseases like cancer.
-
Using electronics to solve common biological problems
Dec 1, 2019
What do an electrical engineer, an organic chemist, a materials scientist and a cell biologist all have in common? They invent and improve applications at the interface of biology and electronics.
-
Argonaute proteins help fine-tune gene expression
Oct 27, 2019
A protein, with a name reminiscent of legendary Greek sailors, has an unexpected role inside the human nucleus.
-
Perfect conditions for precision nanostructures
Oct 14, 2019
Protein-folded DNA nanostructures offer a new building material for biotechnology.
-
Quenching scientific curiosity with single-molecule imaging
Jul 24, 2019
New experimental insights allow researchers to probe protein-DNA interactions with greater precision.
-
Turning up the heat on pathogenic bacteria
Jun 16, 2019
Protein found in gut-dwelling pathogens changes shape under human body temperatures, leading to toxins responsible for diarrheal disease.
-
Global study links newly named syndrome with other disorders
May 16, 2019
Mutations in a repetitive protein motif are responsible for a rare cognitive disorder.
-
Bacterial mix helps predict future change
Apr 15, 2019
Understanding how bacterial metacommunities homogenize could help scientists predict future changes to ecosystems.
-
A fail-safe mechanism for DNA repair
Mar 24, 2019
Single-molecule fluorescent measurements provide fresh insights into a process for keeping errors out of our genomes.
-
Speargrass recruits sandy microbes for help
Mar 13, 2019
In the harsh sand of the Namib Desert, the sheaths of speargrass roots co-opt any growth-promoting bacteria they can find.
-
The fiddlers influencing mangrove ecosystems
Mar 11, 2019
The types of bacteria living in and around fiddler crab burrows vary widely between mangroves, but their functional activities are remarkably similar.
-
Rules of inheritance rewritten in worms
Feb 21, 2019
Laboratory model breaks laws of heredity, opening up new research possibilities in genetics and synthetic biology.
-
Causal disentanglement is the next frontier in AI
Feb 19, 2019
Recreating the human mind’s ability to infer patterns and relationships from complex events could lead to a universal model of artificial intelligence.
-
Lactate triggers genes that modify brain activity
Feb 10, 2019
Study illustrates the links between brain energy metabolism and neuronal activity.
-
New moves for polymer chain dynamics
Jan 21, 2019
A Nobel-winning method for observing single molecules in action provides the basis for unprecedented insights into polymer chain dynamics.
-
Visualization of brain structures helps to model function
Jan 3, 2019
State-of-the-art techniques and software help researchers recreate cellular brain structures and model biochemical processes that support the brain’s energy demands.
-
Paper sensors remove the sting of diabetic testing
Dec 20, 2018
Inkjet-printed device helps monitor a patient’s blood sugar levels without painful needles.
-
The dynamic molecular changes of homing
Aug 5, 2018
Molecules reorganize to slow stem cells down, giving them a chance to adhere to and eventually cross the inner lining of blood vessels into the bone marrow.
-
Bacteria that boost plant pumps against drought
Jul 29, 2018
Adding certain types of bacteria to soil could help protect plants against drought by activating a proton pump in root cells.
-
Taking the lead toward witchweed control
Jul 19, 2018
A compound that binds to and inhibits a crucial receptor protein offers a new route for controlling a parasitic plant.
-
Detecting metabolites at close range
Jun 22, 2018
Pairing a conjugated polymer with a redox enzyme generates a fast, selective and sensitive electrochemical biosensor for metabolites.
-
Boring down on boron
Jun 10, 2018
Learning how boron evaporates will help to improve water desalination technologies.
-
The long and short of DNA replication
May 27, 2018
An unexpected two-step mechanism occurs when cells copy DNA.
-
Enzyme adopts dynamic structure to function in hot, salty sea
May 13, 2018
Protein analysis could lead to new advances in DNA sequencing technologies.
-
Computer models combat malaria
Apr 15, 2018
A new malaria metabolic model may uncover better ways to treat a highly deadly disease.
-
Glaciers provide clues to combat desertification
Mar 4, 2018
Understanding how bacteria help convert glacier bedrock into soil could help address desertification.
-
High salinity protects corals from heat stress
Feb 25, 2018
Corals living in highly saline waters may be more tolerant to rising water temperatures.
-
Giving seagrass its due
Feb 18, 2018
Seagrass meadows play a pivotal role in protecting coasts against rising sea levels.
-
Coral lifestyles reflected in their genes
Jan 28, 2018
A comparison of the genomes of two species of coral demonstrates unexpected genetic diversity.
-
Not just a stem cell marker
Jan 21, 2018
The protein CD34 is predominantly regarded as a marker of blood-forming stem cells but it helps with migration to the bone marrow too.
-
Enzyme from briny deep resurrected in the lab
Jan 14, 2018
Genomes of single microbial cells isolated from the Red Sea could yield a goldmine for biotechnology.
-
The awesome scope of big data
Aug 6, 2017
Sifting through huge amounts of data may bring better understanding of whale shark social structures, protein targets for drug therapies and disease-causing genes.
-
Herbal medicine shows potential to treat cancer
Aug 6, 2017
Herbal remedy plants native to Saudi Arabia are shown to have potential as treatments for cancer.
-
Short regulatory gene spotted
Jun 10, 2017
Two proteins produced by a single gene interact to keep the genome in check.
-
The hidden order in DNA diffusion
Jun 6, 2017
The movement of DNA molecules seemingly explained by random motion conceals a more orderly march.
-
An inflammatory inference
May 20, 2017
The surface proteins responsible for navigating immune cells to sites of inflammation are identified.
-
The brighter side of twisted polymers
May 15, 2017
Conjugated polymers designed with a twist produce tiny, brightly fluorescent particles with broad applications.
-
Interdisciplinarity helps unravel the protein puzzle
May 6, 2017
The work of a small group specializing in demystifying proteins is having far-reaching effects.
-
The carpenter enzyme gives DNA the snip
Apr 1, 2017
Enzyme follows a two-step verification system before cutting and repairing DNA damage.
-
First detection of an artemisinin-resistant malaria parasite contracted in Africa
Feb 21, 2017
Africa now joins Southeast Asia in hosting parasites partially resistant to the first-line antimalaria drug, artemisinin.
-
Driven to diffraction
Nov 9, 2016
Optical elements that diffract light could lead to smaller and more powerful cameras.
-
Leukemia treatment offers hope
Sep 17, 2016
Antibodies directed against cancer stem cells could help patients with acute myeloid leukemia.
-
A deadly delivery for breast cancer
May 28, 2016
Zinc oxide (ZnO) nanoparticles may help destroy difficult-to-treat triple-negative breast cancer tumors.
-
A terminator for truncated transcripts
Apr 23, 2016
A gene linked to plant stress response helps to prevent the production of defective proteins.
-
Pathogen expertise boosted with latest genomics
Feb 13, 2016
Expert knowledge in the field of DNA and RNA sequencing puts KAUST at the forefront of high-impact pathogen research.
-
The brain gamers
Dec 19, 2015
Novel use of gaming technology enables researchers to 'step inside' the brain.
-
Doubled up protein protects against cancer
Sep 26, 2015
Insight into additional functions of a key cancer protein could pave the way for new anti-cancer drugs.
-
Getting to the roots of microRNA
Sep 12, 2015
Proteins that have dual roles in the molecular processing of RNA could be manipulated to produce tougher plants.
-
Helping flowing cells make a connection
Sep 5, 2015
A modern twist on a traditional biochemistry technique lets scientists study interactions that trap cells in circulation.
-
DNA division can slow to a halt
Aug 31, 2015
Termination sites of DNA are shown to stop slow-moving replication forks but not faster ones.
-
Sequencing reveals strains behind cholera outbreak
Mar 28, 2015
Whole-genome sequencing of the bacterium responsible for a cholera outbreak reveals a population structure missed by traditional methods.
-
Exploring the brain by mimicking the brain
Mar 21, 2015
A new collaboration could lead to supercomputers emulating the efficiency of the brain.
-
Plants coping with salt stress
Feb 1, 2015
Discovery of the molecular mechanism by which a protein confers salt tolerance in plants could boost crop yields in high-saline soils.
-
Herbicide resistance: shedding light on the shikimate pathway
Dec 26, 2014
Resistance to a popular herbicide provides insight into the control of a key biosynthetic pathway.
-
Run for your brain
Dec 26, 2014
Lactate plays an unexpected role in brain function.
-
Molecular movie reveals enzyme’s mechanism of action
Dec 24, 2014
An enzyme involved in maintaining genome fidelity goes through seven steps to recognize its DNA substrates.
-
Parasite scan yields new targets
Dec 20, 2014
Enzymes crucial to parasite growth offer clues in fight against malaria.
